Cost and clinical outcome of islet transplantation in Norway 2010-2015

Research output: Contribution to journalArticle

Abstract

Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet transplantation alone (ITA), while five patients received islet transplantation after previous solid organ transplantation. For the group receiving 2 ITA, Kaplan-Meier estimates show an insulin independence of 20% more than 4 years after their last transplantation. An estimated 70% maintain at least partial graft function, defined as fasting C-peptide >0.1 nmol L−1, and 47% maintain a HbA1c below 6.5% or 2 percent points lower than before ITA. For all groups combined, we estimate that 44% of the patients have a 50% reduction in insulin requirement 4 years after the initial islet transplantation. The average cost for an islet transplantation procedure was 347 297±60 588 NOK, or 35 424±6182 EUR, of which isolation expenses represent 34%. We hereby add to the common pool of growing experience with islet transplantation and also describe the cost of the treatment at our center.

Details

Authors
  • Simen W. Schive
  • Aksel Foss
  • Afaf Sahraoui
  • Kristine Kloster-Jensen
  • Geir Hafsahl
  • Gunnar Kvalheim
  • Torbjørn Lundgren
  • Bengt von Zur-Mühlen
  • Marie Felldin
  • Ehab Rafael
  • Marko Lempinen
  • Olle Korsgren
  • Trond G. Jenssen
  • Vinod Mishra
  • Hanne Scholz
Organisations
External organisations
  • University of Oslo
  • Oslo university hospital
  • Karolinska Institutet
  • Uppsala University Hospital
  • Sahlgrenska University Hospital
  • Skåne University Hospital
  • Uppsala University
  • UiT The Arctic University of Norway, Tromsø
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery

Keywords

  • cost, islet transplantation, outcome, type 1 diabetes
Original languageEnglish
Article numbere12871
JournalClinical Transplantation
Volume31
Issue number1
Publication statusPublished - 2017 Jan 1
Publication categoryResearch
Peer-reviewedYes