C-reactive protein concentrations and level of physical activity in men and women with normal and impaired glucose tolerance: A cross-sectional population-based study in Sweden

Research output: Contribution to journalArticle


Background: We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT). Methods: In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study. Results: An inverse association between LTPA and CRP concentrations was observed in the population (P <.001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (Δ0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (Δ0.01 mg/L, P = .944). Conclusions: Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT.


  • Margareta I. Hellgren
  • Charlotte A. Larsson
  • Bledar Daka
  • Max Petzold
  • Per Anders Jansson
  • Ulf Lindblad
External organisations
  • University of Gothenburg
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Medicine


  • Gender differences, Glucose metabolism, Inflammation
Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalJournal of Physical Activity & Health
Issue number6
Publication statusPublished - 2016 Jun 1
Publication categoryResearch