Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group

Research output: Contribution to journalArticle

Abstract

The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/l and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is greater than or equal to 30 g/l and/or bone marrow clonal cells greater than or equal to 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTI. Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.

Details

Authors
  • RA Kyle
  • JA Child
  • K Anderson
  • B Barlogie
  • R Bataille
  • W Bensinger
  • J Blade
  • M Boccadoro
  • W Dalton
  • M Dimopoulos
  • B Djulbegovic
  • M Drayson
  • B Durie
  • T Facon
  • R Fonseca
  • G Gahrton
  • P Greipp
  • JL Harousseau
  • D Harrington
  • M Hussein
  • D Joshua
  • H Ludwig
  • G Morgan
  • M Oken
  • R Powles
  • P Richardson
  • D Roodman
  • J San Miguel
  • K Shimizu
  • C Shustik
  • B Sirohi
  • P Sonneveld
  • G Tricot
  • B Van Ness
  • D Vesole
  • D Weber
  • Jan Westin
  • K Wheatley
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • monoclonal, classification, multiple myeloma, gammopathies
Original languageEnglish
Pages (from-to)749-757
JournalBritish Journal of Haematology
Volume121
Issue number5
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Stem Cell Center (013041110), Emergency medicine/Medicine/Surgery (013240200)