Crossed over repair of the femoral sensory and motor branches influences N-CAM

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Abstract

N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • neurofilaments, nerve repair, nerve regeneration, N-CAM, axons, misdirection, non-myelinating, Schwann cells
Original languageEnglish
Pages (from-to)841-845
JournalNeuroReport
Volume21
Issue number12
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes