Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals

Research output: Contribution to journalArticle

Abstract

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.

Details

Authors
Organisations
External organisations
  • University of Debrecen
  • Danish Serum Institute, Copenhagen
  • National Public Health Laboratory
  • University of Southern Denmark
  • Karolinska Institutet
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
  • Immunology in the medical area
Original languageEnglish
Pages (from-to)1749–1754
JournalThe Journal of infectious diseases
Volume219
Issue number11
Early online date2019 Feb 2
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes