Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster
Research output: Contribution to journal › Article
beta-Alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 angstrom at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 angstrom, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Acta Crystallographica. Section F: Structural Biology and Crystallization Communications|
|Publication status||Published - 2007|