CSF biomarkers in suicide attempters - a principal component analysis.

Research output: Contribution to journalArticle


title = "CSF biomarkers in suicide attempters - a principal component analysis.",
abstract = "Lindqvist D, Janelidze S, Erhardt S, Tr{\"a}skman-Bendz L, Engstr{\"o}m G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug-free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well-defined psychiatric rating scales and followed-up regarding future suicide. We used principal component analysis to identify factors among the biological substances. Results: Four factors were extracted from the 20 biomarkers, explaining 52.4{\%} of the total variance. Factors 1 and 2 were characterized by high loadings of chemokines and cytokines respectively. They were both associated with severe depressive symptoms. Factor 2 was also associated with a high suicidal intent. Factor 4 was characterized by strong loadings of the monoamine metabolites 5-HIAA and HVA, as well as orexin and interleukin-6. High scores on this factor were found in patients who performed a violent suicide attempt and in patients who subsequently completed suicide. Conclusion: Our results suggest that specific combinations of CSF biomarkers may discriminate between types of suicidal behaviour and indicate increased risk for future suicide.",
author = "Daniel Lindqvist and Shorena Janelidze and S Erhardt and {Tr{\"a}skman Bendz}, Lil and Gunnar Engstr{\"o}m and Lena Brundin",
year = "2011",
doi = "10.1111/j.1600-0447.2010.01655.x",
language = "English",
volume = "124",
pages = "52--61",
journal = "Acta Psychiatrica Scandinavica",
issn = "1600-0447",
publisher = "Wiley-Blackwell",