CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Research output: Contribution to journalArticle

Abstract

We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

Details

Authors
  • Tobias Skillbäck
  • Bahman Farahmand
  • Jonathan W Bartlett
  • Christoffer Rosén
  • Niklas Mattsson
  • Katarina Nägga
  • Lena Kilander
  • Dorota Religa
  • Anders Wimo
  • Bengt Winblad
  • Lars Rosengren
  • Jonathan M Schott
  • Kaj Blennow
  • Maria Eriksdotter
  • Henrik Zetterberg
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)1945-1953
JournalNeurology
Volume83
Issue number21
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes