Cubosomes for in vivo fluorescence lifetime imaging

Research output: Contribution to journalArticle


title = "Cubosomes for in vivo fluorescence lifetime imaging",
abstract = "Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection.",
keywords = "fluorescence lifetime probe, fluorescence optical imaging in vivo, liquid crystalline nanoparticles",
author = "Stefania Biffi and Laura Andolfi and Claudia Caltagirone and Chiara Garrovo and Falchi, {Angela M} and Vito Lippolis and Andrea Lorenzon and Paolo Macor and Valeria Meli and Maura Monduzzi and Marc Obiols-Rabasa and Luca Petrizza and Luca Prodi and Antonella Rosa and Judith Schmidt and Yeshayahu Talmon and Sergio Murgia",
year = "2017",
month = "2",
day = "3",
doi = "10.1088/1361-6528/28/5/055102",
language = "English",
volume = "28",
journal = "Nanotechnology",
issn = "0957-4484",
publisher = "IOP Publishing",
number = "5",