Current progress of adhesins as vaccine candidates for Moraxella catarrhalis

Research output: Contribution to journalReview article

Abstract

Moraxello catorrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine candidates is discussed with a focus on various candidate antigens that spanned those discovered more than 10 years ago, for example, the ubiquitous surface proteins to newer antigens, such as the Moraxella IgD-binding hemagglutinin.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area

Keywords

  • surface protein A1/A2, ubiquitous, outer membrane protein CD, OLpA, IgD binding protein/hag, Moraxella, Moraxella catarrhalis, mcmA, filamentous hemagglutinin, McaP
Original languageEnglish
Pages (from-to)949-956
JournalExpert Review of Vaccines
Volume6
Issue number6
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes