Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1

Research output: Contribution to journalArticle

Abstract

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

Details

Authors
  • Renée F. de Pooter
  • Sheila Dias
  • Munmun Chowdhury
  • Elisabeth T. Bartom
  • Michael K. Okoreeh
  • Mikael Sigvardsson
  • Barbara L. Kee
Organisations
External organisations
  • University of Chicago
  • Northwestern University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
Original languageEnglish
Pages (from-to)2837-2842
Number of pages6
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume202
Issue number10
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes