Cyclin e overexpression reduces infiltrative growth in breast cancer - Yet another link between proliferation control and tumor invasion

Research output: Contribution to journalArticle

Abstract

Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

Details

Authors
  • Pontus Berglund
  • Göran Landberg
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell Biology

Keywords

  • medullary breast, proliferation, invasion, breast cancer, cyclin E, microarray, cancer
Original languageEnglish
Pages (from-to)606-609
JournalCell Cycle
Volume5
Issue number6
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes