Cyclodextrin-surfactant complex: A new route in DNA decompaction

Research output: Contribution to journalArticle


title = "Cyclodextrin-surfactant complex: A new route in DNA decompaction",
abstract = "In the present work, we show a new approach for decompaction of DNA-cationic surfactant complexes, e.g., lipoplexes, by using beta-cyclodextrin (beta-CD). The DNA decompaction was achieved by dissolving the surfactant aggregates in the complex by making use of the high affinity between the beta-CD and the free surfactant in solution. The results from fluorescence microscopy and adiabatic compressibility measurements indicate that coils and globules do not coexist. The reported procedure using beta-CD is an efficient way to decompact DNA surfactant complexes because the association constant of surfactants with beta-CD is large. The surfactant's interaction with beta-CD is specific and the nonspecific interaction between beta-CD and biological interfaces is small.",
author = "{Gonzalez Perez}, Alfredo and Rita Dias and Tommy Nylander and Bj{\"o}rn Lindman",
year = "2008",
doi = "10.1021/bm7012907",
language = "English",
volume = "9",
pages = "772--775",
journal = "Biomacromolecules",
issn = "1526-4602",
publisher = "The American Chemical Society (ACS)",
number = "3",