Cytogenetic abnormalities in a hemangiopericytoma of the spleen.

Research output: Contribution to journalArticle

Abstract

To date, only 16 cytogenetically abnormal hemangiopericytomas (HP) have been reported. Despite this low number, some characteristic karyotypic features have already emerged: most HP are near-diploid and breakpoints in 12q13, 12q24, and 19q13 seem to be common, with t(12;19)(q13;q13) being a recurrent translocation. Here, we report the first case of a probably benign splenic HP with chromosomal abnormalities. The abnormal karyotype was 47,XX,t(5;22;11)(q31;q11;q13),+10. None of these abnormalities have previously been reported in HP, suggesting that the karyotypic pattern of splenic HP may differ from soft tissue HP.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ)

  • Surgery
  • Medical Genetics
  • Cancer and Oncology

Keywords

  • Male, Karyotyping, Immunohistochemistry, Human, Hemangiopericytoma : genetics, Female, Cytogenetic Analysis, Case Report, Chromosome Aberrations, Splenic Neoplasms : genetics
Original languageEnglish
Pages (from-to)62-65
JournalCancer Genetics and Cytogenetics
Volume136
Issue number1
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery (Lund) (013009000), Division of Clinical Genetics (013022003), Pathology, (Lund) (013030000), Surgery Research Unit (013242220)