Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

Research output: Contribution to journalArticle

Abstract

Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.

Details

Authors
Organisations
External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
  • Urology and Nephrology

Keywords

  • Adolescent, Child, Child, Preschool, Cytokines, Female, Hemolytic-Uremic Syndrome, Humans, Infant, Interleukin-6, Male, Purpura, Thrombotic Thrombocytopenic, Renal Dialysis, Serum Globulins, Tumor Necrosis Factor-alpha, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)694-9
Number of pages6
JournalPediatric Nephrology
Volume9
Issue number6
Publication statusPublished - 1995 Dec
Publication categoryResearch
Peer-reviewedYes