Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

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Bibtex

@article{4992100e20e4404aa4497c47ecb5aea7,
title = "Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura",
abstract = "Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94{\%}) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20{\%}) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.",
keywords = "Adolescent, Child, Child, Preschool, Cytokines, Female, Hemolytic-Uremic Syndrome, Humans, Infant, Interleukin-6, Male, Purpura, Thrombotic Thrombocytopenic, Renal Dialysis, Serum Globulins, Tumor Necrosis Factor-alpha, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't",
author = "D Karpman and Annika Andreasson and H Thysell and Kaplan, {B S} and C Svanborg",
year = "1995",
month = "12",
doi = "10.1007/BF00868714",
language = "English",
volume = "9",
pages = "694--9",
journal = "Pediatric Nephrology",
issn = "1432-198X",
publisher = "Springer",
number = "6",

}