Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

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Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. / Karpman, D; Andreasson, Annika; Thysell, H; Kaplan, B S; Svanborg, C.

In: Pediatric Nephrology, Vol. 9, No. 6, 12.1995, p. 694-9.

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Karpman, D ; Andreasson, Annika ; Thysell, H ; Kaplan, B S ; Svanborg, C. / Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. In: Pediatric Nephrology. 1995 ; Vol. 9, No. 6. pp. 694-9.

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TY - JOUR

T1 - Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

AU - Karpman, D

AU - Andreasson, Annika

AU - Thysell, H

AU - Kaplan, B S

AU - Svanborg, C

PY - 1995/12

Y1 - 1995/12

N2 - Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.

AB - Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not detected in the serum (n = 25) and urine (n = 15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Cytokines

KW - Female

KW - Hemolytic-Uremic Syndrome

KW - Humans

KW - Infant

KW - Interleukin-6

KW - Male

KW - Purpura, Thrombotic Thrombocytopenic

KW - Renal Dialysis

KW - Serum Globulins

KW - Tumor Necrosis Factor-alpha

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/BF00868714

DO - 10.1007/BF00868714

M3 - Article

VL - 9

SP - 694

EP - 699

JO - Pediatric Nephrology

T2 - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 1432-198X

IS - 6

ER -