De zuigeling met een vitamine-K-deficiëntiebloeding ondanks adequate profylaxe

Research output: Contribution to journalArticle


Vitamin K deficiency in infants can cause life-threatening haemorrhages. To prevent this, neonates in the Netherlands receive an oral dose of 1 mg vitamin K directly after birth. In addition, because breast milk contains little vitamin K, breast-fed infants receive a daily dose of 25 μg the first three months. Of three female infants aged 4 weeks, 5 months and 3 months, respectively, two developed an intracranial haemorrhage, which caused death in one. In two cases there were signs of a bleeding tendency, but no tests were done because the patients appeared healthy otherwise. The underlying resorptive disorders, cholestasis and fat malabsorption, caused few symptoms and were discovered only after a vitamin K deficiency bleeding had occurred. In an infant with a bleeding tendency, one should consider the possibility of vitamin K deficiency, even if adequate prophylaxis has been given.


External organisations
  • Wilhelmina Children’s Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
Translated title of the contributionVitamin K deficiency bleeding in an infant despite adequate prophylaxis
Original languageDutch
Pages (from-to)737-740
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Issue number16
Publication statusPublished - 2003 Apr 19
Publication categoryResearch
Externally publishedYes