Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Research output: Contribution to journalArticle

Abstract

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Details

Authors
  • Oliver Kluth
  • Mandy Stadion
  • Pascal Gottmann
  • Heja Aga
  • Markus Jähnert
  • Stephan Scherneck
  • Heike Vogel
  • Ulrika Krus
  • Anett Seelig
  • Charlotte Ling
  • Jantje Gerdes
  • Annette Schürmann
Organisations
External organisations
  • German Institute of Human Nutrition
  • Technical University of Braunschweig
  • Helmholtz Zentrum München
  • University of Potsdam
  • German Center for Diabetes Research
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Endocrinology and Diabetes

Keywords

  • beta-cell proliferation, cilia genes, human pancreatic islets, islet transcriptomics, New Zealand Obese mouse, pathway enrichment analysis, primary cilia, type 2 diabetes
Original languageEnglish
Pages (from-to)3027-3036.e3
JournalCell Reports
Volume26
Issue number11
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes