Decreasing cumulative incidence of end-stage renal disease in young patients with type 1 diabetes in Sweden: A 38-year prospective nationwide study

Research output: Contribution to journalArticle


OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset of diabetes 0–34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS We found that the cumulative incidence of ESRD in Sweden was low after up to 38 years of diabetes duration (5.6%). The incidence of ESRD was lower in patients with type 1 diabetes onset in 1991–2001 compared with onset in 1977–1984 and 1985–1990, independent of diabetes duration. CONCLUSIONS The risk of developing ESRD in Sweden in this population is still low and also seems to decrease with time.


  • Swedish Childhood Diabetes Study Group
  • Cecilia Toppe
  • Anna Möllsten
  • Ingeborg Waernbaum
  • Staffan Schön
  • Soffia Gudbjörnsdottir
  • Mona Landin-Olsson
  • Gisela Dahlquist
External organisations
  • Umeå University
  • Ryhov County Hospital, Jönköping
  • Swedish Renal Registry
  • Sweden National Diabetes Register
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
  • Urology and Nephrology
Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalDiabetes Care
Issue number1
Publication statusPublished - 2019
Publication categoryResearch