Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats

Research output: Contribution to journalArticle

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.

Details

Authors
  • Wassilios G. Meissner
  • Daniel Harnack
  • Gesine Paul
  • Torsten Reum
  • Reinhard Sohr
  • Rudolf Morgenstern
  • Andreas Kupsch
External organisations
  • Humboldt University of Berlin
Research areas and keywords

Keywords

  • 3,4-Dihydroxyphenylacetic Acid, Animals, Cell Death, Disease Models, Animal, Dopamine, Electric Stimulation Therapy, Functional Laterality, Male, Neostriatum, Neural Pathways, Oxidopamine, Parkinsonian Disorders, Rats, Rats, Wistar, Rotation, Substantia Nigra, Subthalamic Nucleus, Sympatholytics, Tyrosine 3-Monooxygenase, Up-Regulation, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)105-8
Number of pages4
JournalNeuroscience Letters
Volume328
Issue number2
Publication statusPublished - 2002 Aug 9
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes