Deformability-based sorting of red blood cells in deterministic lateral displacement devices

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.

Details

Authors
Organisations
External organisations
  • Jülich Research Centre
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Laboratory and Measurements Technologies

Keywords

  • Bumper array, Mesoscopic simulation, Microfluidics, Post shape
Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages788-789
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 2016 Oct 92016 Oct 13

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period2016/10/092016/10/13