Dehydration affects drug transport over nasal mucosa

Research output: Contribution to journalArticle

Abstract

Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and 51Cr-EDTA uptake was studied separately ex vivo using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and 51Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm® (Nordic Drugs, Sweden) and BLOX4® (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle in situ or preventing dehydration of the mucosa is the most important factor for improving bioavailability.

Details

Authors
Organisations
External organisations
  • Malmö University
  • Bioglan AB
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmaceutical Sciences

Keywords

  • dehydration, drug transport, Mucoadhesion, nasal drug delivery, water activity
Original languageEnglish
Pages (from-to)831-840
Number of pages10
JournalDrug delivery
Volume26
Issue number1
Publication statusPublished - 2019 Jan 1
Publication categoryResearch
Peer-reviewedYes