Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia on the day of birth or jaundice in the first 4 weeks

Research output: Contribution to journalReview article


AIM: Our aim was to investigate the effects of timing of cord clamping on the risk of hyperbilirubinaemia.

METHODS: We recruited 540 normal vaginal deliveries at the Paropakar Maternity and Women's Hospital in Kathmandu, Nepal, from 2 October to 21 November 2014. They were randomised into two groups: 257/270 were cord clamped within 60 seconds and 209/270 after 180 seconds. Transcutaneous bilirubin was measured at discharge and 24 hours. At four weeks, 506 mothers were successfully contacted by phone and the health status of the baby and their history of jaundice and treatment was recorded.

RESULTS: Based on transcutaneous bilirubin at discharge, 22/261 (8.4%) in the early group and 25/263 (9.5%) in the delayed group (p=0.76) were at high risk of subsequent hyperbilirubinemia. At the four-week follow up, jaundice was reported in 13/253 (5.1%) in the early and 17/253 (6.7%) in the delayed group (p=0.57) and 3/253 (1.2 %) of the early and 1/253 (0.4%) of the delayed group (p= 0.62) received treatment. All analyses were based on intention-to-treat.

CONCLUSION: Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia during the first day of life or risk of jaundice within four weeks compared with the early group. This article is protected by copyright. All rights reserved.


  • Nisha Rana
  • Linda Jarawka Ranneberg
  • Mats Målqvist
  • Ashish Kc
  • Ola Andersson
External organisations
  • Uppsala University
  • Region Halland
  • UNICEF, Nepal
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
Original languageEnglish
Pages (from-to)71-77
JournalActa Pædiatrica
Issue number1
Early online date2019 Jun 25
Publication statusPublished - 2020
Publication categoryResearch