Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]

Research output: Contribution to journalArticle

Abstract

This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology

Keywords

  • symptomatische Bakteriurie, E. coli 83972, P-Fimbrien, Harnwegsinfektionen, Wirtsreaktion
Original languageGerman
Pages (from-to)233-237
JournalDer Urologe
Volume42
Issue number2
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes