Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
Research output: Contribution to journal › Article
The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identified.
|Research areas and keywords||
|Journal||Bioorganic & Medicinal Chemistry Letters|
|Publication status||Published - 2010 Dec 1|