Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
Research output: Contribution to journal › Article
Abstract
The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identified.
Details
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| Research areas and keywords | Keywords
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| Original language | English |
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| Pages (from-to) | 6925-6928 |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 20 |
| Issue number | 23 |
| Publication status | Published - 2010 Dec 1 |
| Publication category | Research |
| Peer-reviewed | Yes |
| Externally published | Yes |
