Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Fusion gene, Gene expression, NanoString, Non-small cell lung carcinoma
Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages91-107
Number of pages17
Volume2279
ISBN (Print)978-1-0716-1278-1
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes

Publication series

NameMethods in Molecular Biology
Volume2279
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029