Detection of pre-plaque amyloid aggregation using FTIR

Research output: Contribution to journalArticle

Abstract

Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.

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Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Neurology
  • Accelerator Physics and Instrumentation
Original languageEnglish
JournalAlzheimer's and Dementia
Volume10
Issue number4
Publication statusPublished - 2014 Jul 1
Publication categoryResearch
Peer-reviewedYes