Determination of optical scattering properties of highly-scattering media in optical coherence tomography images

Research output: Contribution to journalArticle

Abstract

We developed a new algorithm that fits optical coherence tomography (OCT) signals as a function of depth to a general theoretical OCT model which takes into account multiple scattering effects. With use of this algorithm, it was possible to extract both the scattering coefficient and anisotropy factor from a particular region of interest in an OCT image. The extraction algorithm was evaluated against measurements from an integrating sphere on a set of tissue phantoms and yielded valid results. Finally, a preliminary ex vivo OCT investigation on human aortic specimen indicated that the algorithm may contribute importantly to differentiation between normal and atherosclerotic arteries. We conclude that this algorithm may facilitate tissue characterization by OCT. (C) 2004 Optical Society of America.

Details

Authors
  • D Levitz
  • L Thrane
  • MH Frosz
  • PE Andersen
  • CB Andersen
  • J Valanciunaite
  • Johannes Swartling
  • Stefan Andersson-Engels
  • PR Hansen
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Atom and Molecular Physics and Optics
Original languageEnglish
Pages (from-to)249-259
JournalOptics Express
Volume12
Issue number2
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes

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