Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro

Research output: Contribution to journalArticle


Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro.


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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences


  • Cell culture, T4-O, Myelination, Development, White matter, Spinal cord, Oligodendrocyte, Chicken
Original languageEnglish
Pages (from-to)21-24
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 2000
Publication categoryResearch
Externally publishedYes