Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study

Research output: Contribution to journalArticle

Abstract

Objective: To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design: We included 17,153 men and 18,682 women from a population-based cohort, aged 35–70 years at baseline (1995–1997). Incident hand OA were obtained from diagnostic codes in the Norwegian National Patient Register (1995–2018). We studied whether a range of self-reported and clinically measured predictors could predict hand OA, using the Area Under the receiver-operating Curve (AUC) from logistic regression. External validation of an existing prediction model for male hand OA was tested on discrimination in a sample of men. Bootstrapping was used to avoid overfitting. Results: The model for men showed modest discriminatory ability (AUC = 0.67, 95% CI 0.62–0.71). Adding a genetic risk score did not improve prediction. Similar discrimination was observed in the model for women (AUC = 0.62, 95% CI 0.59–0.64). Prediction was not improved by adding a genetic risk score or hormonal and reproductive factors. Applying external validation, similar results were observed among men in HUNT (The Nord-Trøndelag Health Study) as in the developmental sample (AUC = 0.62, 95% CI 0.57–0.65). Conclusion: We developed prediction models for incident hand OA in men and women. For women, the model included body mass index (BMI), heavy physical work, high physical activity and perceived poor health. The model showed moderate discrimination. For men, we have shown that a prediction model including BMI, education and information on sleep can predict incident hand OA in several populations with moderate discriminative ability.

Details

Authors
  • M. B. Johnsen
  • K. Magnusson
  • S. Børte
  • M. E. Gabrielsen
  • B. S. Winsvold
  • A. H. Skogholt
  • L. Thomas
  • K. Storheim
  • K. Hveem
  • J. A. Zwart
Organisations
External organisations
  • University of Oslo
  • Oslo university hospital
  • Norwegian University of Science and Technology
  • National Advisory Unit on Rehabilitation in Rheumatology
  • Diakonhjemmet Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology
  • Orthopedics

Keywords

  • Discrimination, Hand, Osteoarthritis, Prediction, Risk
Original languageEnglish
Pages (from-to)932-940
Number of pages9
JournalOsteoarthritis and Cartilage
Volume28
Issue number7
Early online date2020 Apr 21
Publication statusPublished - 2020 Jul 1
Publication categoryResearch
Peer-reviewedYes