Development of a physical 3D anthropomorphic breast phantom

Research output: Contribution to journalArticle

Abstract

Purpose: Develop a technique to fabricate a 3D anthropomorphic breast phantom with known ground truth for image quality assessment of 2D and 3D breast x-ray imaging systems. Methods: The phantom design is based on an existing computer model that can generate breast voxel phantoms of varying composition, size, and shape. The physical phantom is produced in two steps. First, the portion of the voxel phantom consisting of the glandular tissue, skin, and Cooper's ligaments is separated into sections. These sections are then fabricated by high-resolution rapid prototyping using a single material with 50% glandular equivalence. The remaining adipose compartments are then filled using an epoxy-based resin (EBR) with 100% adipose equivalence. The phantom sections are stacked to form the physical anthropomorphic phantom. Results: The authors fabricated a prototype phantom corresponding to a 450 ml breast with 45% dense tissue, deformed to a 5 cm compressed thickness. Both the rapid prototype (RP) and EBR phantom materials are radiographically uniform. The coefficient of variation (CoV) of the relative attenuation between RP and EBR phantom samples was <1% and the CoV of the signal intensity within RP and EBR phantom samples was <1.5% on average. Digital mammography and reconstructed digital breast tomosynthesis images of the authors' phantom were reviewed by two radiologists; they reported that the images are similar in appearance to clinical images, noting there are still artifacts from air bubbles in the EBR. Conclusions: The authors have developed a technique to produce 3D anthropomorphic breast phantoms with known ground truth, yielding highly realistic x-ray images. Such phantoms may serve both qualitative and quantitative performance assessments for 2D and 3D breast x-ray imaging systems.

Details

Authors
  • Ann Katherine Carton
  • Predrag Bakic
  • Christer Ullberg
  • Helen Derand
  • Andrew D.A. Maidment
External organisations
  • University of Pennsylvania
  • XCounter AB
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Image Processing

Keywords

  • anthropomorphic breast phantom, breast x-ray imaging, digital breast tomosynthesis, image quality assessment, mammography
Original languageEnglish
Pages (from-to)891-896
Number of pages6
JournalMedical Physics
Volume38
Issue number2
Publication statusPublished - 2011 Feb
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes