Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.

Research output: Contribution to journalReview article


Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.


  • T Bölling
  • G Braun-Munzinger
  • S Burdach
  • G Calaminus
  • A Craft
  • O Delattre
  • M-C L Deley
  • U Dirksen
  • B Dockhorn-Dworniczak
  • J Dunst
  • S Engel
  • A Faldum
  • B Fröhlich
  • H Gadner
  • U Göbel
  • G Gosheger
  • J Hardes
  • D S Hawkins
  • C Hoffmann
  • H Kovar
  • J Kruseova
  • R Ladenstein
  • I Leuschner
  • I J Lewis
  • O Oberlin
  • M Paulussen
  • J Potratz
  • A Ranft
  • C Rössig
  • C Rübe
  • R Sauer
  • O Schober
  • A Schuck
  • B Timmermann
  • F Tirode
  • H van den Berg
  • F van Valen
  • V Vieth
  • N Willich
  • W Winkelmann
  • J Whelan
  • R B Womer
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
Original languageEnglish
Pages (from-to)108-115
JournalKlinische Pädiatrie
Issue number3
Publication statusPublished - 2015
Publication categoryResearch