Development of Humanized Ossicles: Bridging the Hematopoietic Gap

Research output: Contribution to journalReview article

Abstract

Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits. Ultimately, we propose directions for the development of hOss as a technological platform for human hematopoietic studies.

Details

Authors
Organisations
External organisations
  • Ottawa Hospital Research Institute
  • University of Ottawa
  • The Ottawa Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • bone marrow niche, bone tissue engineering, hematopoiesis, hematopoietic stem cells, humanized ossicle, mesenchymal stromal cells
Original languageEnglish
JournalTrends in Molecular Medicine
Publication statusE-pub ahead of print - 2020 Mar 3
Publication categoryResearch
Peer-reviewedYes