Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes

Research output: Contribution to journalArticle

Abstract

Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number ofdifferences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for thephenotypes.

Details

Authors
  • Helle Markholst
  • Susan Eastman
  • Deborah Wilson
  • Bodil E. Andreasen
  • Åke Lernmark
External organisations
  • University of Washington
  • Hagedorn Research Institute
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalJournal of Experimental Medicine
Volume174
Issue number1
Publication statusPublished - 1991 Jul 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes