Diabetic retinopathy in type 1 diabetes mellitus. A study on medical risk indicators and treatment outcome.

Research output: ThesisDoctoral Thesis (compilation)

Abstract

Diabetic retinopathy is a common complication to diabetes mellitus and is still a major cause of impaired vision in the Western world. The aim of the present study was to identify medical risk factors influencing the development and progression of retinopathy in type 1 diabetic patients, and to investigate the effects of laser treatment on visual acuity and glare.

Although the development of sight-threatening retinopathy during a 10-year follow-up period was 37%, less than 1% of the patients became blind (VA£0.1). The development of retinopathy was associated with hyperglycemia and to some extent, a high blood pressure. In patients followed from the onset of the disease, no patient developed sight-threatening retinopathy during the first 10 years. Pregnancy per se did not seem to be a risk factor for progression of retinopathy but preeclampsia during pregnancy was. Although nephropathy and severe retinopathy are closely associated, we identified a subgroup of patients with proliferative retinopathy who did not develop any signs of nephropathy during 10 years of follow-up. Homocysteine did not seem to be an independent risk factor for retinopathy. Patients treated with photocoagulation for clinically significant macular edema had few complications and a good visual outcome. Despite a good visual outcome, many patients with panretinal photocoagulation for proliferative retinopathy express problems with glare. We could confirm their symptoms by demonstrating a prolonged visual recovery time during glare exposure. Thus, patients with type 1 diabetes mellitus who develop sight-threatening retinopathy can expect a good visual outcome due to early detection and photocoagulation treatment. Hyperglycemia and to some extent high blood pressure are risk factors for its development.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology

Keywords

  • Ophtalmology, treatment outcome, risk-indicators, Type 1 diabetes, sight-threatening retinopathy, Oftalmologi
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
  • [unknown], [unknown], Supervisor, External person
Award date2000 May 19
Publisher
  • Monica Lövestam-Adrian Ögonkliniken, Universitetssjukhuset i Lund, 221 85 Lund,
Print ISBNs91-628-4115-7
Publication statusPublished - 2000
Publication categoryResearch

Bibliographic note

Defence details Date: 2000-05-19 Time: 10:15 Place: Segerfalksalen, Wallenberg Neurocenter, Sölvegatan 17, Lund External reviewer(s) Name: Alm, Albert Title: Prof Affiliation: [unknown] ---