Diagnostic criteria for multiple sclerosis: 2005 Revisions to the "McDonald Criteria"

Research output: Contribution to journalArticle


New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity.


  • CH Polman
  • SC Reingold
  • G Edan
  • M Filippi
  • HP Hartung
  • L Kappos
  • FD Lublin
  • LM Metz
  • HF McFarland
  • PW O'Connor
  • Magnhild Sandberg Wollheim
  • AJ Thompson
  • BG Weinshenker
  • JS Wolinsky
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)840-846
JournalAnnals of Neurology
Issue number6
Publication statusPublished - 2005
Publication categoryResearch