Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study

Research output: Contribution to journalArticle


title = "Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study",
abstract = "Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95{\%} CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors.",
author = "Camille Lassale and Gunter, {Marc J.} and Dora Romaguera and Peelen, {Linda M.} and {Van Der Schouw}, {Yvonne T.} and Beulens, {Joline W J} and Heinz Freisling and Muller, {David C.} and Pietro Ferrari and Inge Huybrechts and Guy Fagherazzi and Boutron-Ruault, {Marie Christine} and Aur{\'e}lie Affret and Kim Overvad and Dahm, {Christina C.} and Anja Olsen and Nina Roswall and Tsilidis, {Konstantinos K.} and Katzke, {Verena A.} and Tilman K{\"u}hn and Brian Buijsse and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Emilio S{\'a}nchez-Cantalejo and Nerea Etxezarreta and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Catalina Bonet and Khaw, {Kay Tee} and Key, {Timothy J.} and Antonia Trichopoulou and Christina Bamia and Pagona Lagiou and Domenico Palli and Claudia Agnoli and Rosario Tumino and Francesca Fasanelli and Salvatore Panico and Bueno-de-Mesquita, {H. Bas} and Boer, {Jolanda M A} and Emily Sonestedt and Nilsson, {Lena Maria} and Frida Renstr{\"o}m and Elisabete Weiderpass and Guri Skeie and Eiliv Lund and Moons, {Karel G M} and Elio Riboli and Ioanna Tzoulaki",
year = "2016",
month = "7",
day = "1",
doi = "10.1371/journal.pone.0159025",
language = "English",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",