Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region

Research output: Contribution to journalArticle


Methodological differences in assessing dietary acrylamide (AA) often hamper comparisons of intake across populations. Our aim was to describe the mean dietary AA intake in 27 centers of 10 European countries according to selected lifestyle characteristics and its contributing food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In this cross-sectional analysis, 36 994 men and women, aged 35-74 years completed a single, standardized 24-hour dietary recall using EPIC-Soft. Food consumption data were matched to a harmonized AA database. Intake was computed by gender and center, and across categories of habitual alcohol consumption, smoking status, physical activity, education, and body mass index (BMI). Adjustment was made for participants' age, height, weight, and energy intake using linear regression models. Adjusted mean AA intake across centers ranged from 13 to 47 mu g/day in men and from 12 to 39 mu g/day in women; intakes were higher in northern European centers. In most centers, intake in women was significantly higher among alcohol drinkers compared with abstainers. There were no associations between AA intake and physical activity, BMI, or education. At least 50 % of AA intake across centers came from two food groups "bread, crisp bread, rusks" and "coffee." The third main contributing food group was "potatoes". Dietary AA intake differs greatly among European adults residing in different geographical regions. This observed heterogeneity in AA intake deserves consideration in the design and interpretation of population-based studies of dietary AA intake and health outcomes.


  • Heinz Freisling
  • Aurelie Moskal
  • Pietro Ferrari
  • Genevieve Nicolas
  • Viktoria Knaze
  • Francoise Clavel-Chapelon
  • Marie-Christine Boutron-Ruault
  • Laura Nailler
  • Birgit Teucher
  • Verena A. Grote
  • Heiner Boeing
  • Matthias Clemens
  • Anne Tjonneland
  • Anja Olsen
  • Kim Overvad
  • J. Ramon Quiros
  • Eric J. Duell
  • Maria-Jose Sanchez
  • Pilar Amiano
  • Maria-Dolores Chirlaque
  • Aurelio Barricarte
  • Kay-Tee Khaw
  • Nicholas J. Wareham
  • Francesca L. Crowe
  • Valentina Gallo
  • Eleni Oikonomou
  • Androniki Naska
  • Antonia Trichopoulou
  • Domenico Palli
  • Claudia Agnoli
  • Rosario Tumino
  • Silvia Polidoro
  • Amalia Mattiello
  • H. Bas Bueno-de-Mesquita
  • Marga C. Ocke
  • Petra H. M. Peeters
  • Ingvar A. Bergdahl
  • Ingegerd Johansson
  • Anette Hjartaker
  • Dagrun Engeset
  • Guri Skeie
  • Elio Riboli
  • Nadia Slimani
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics


  • Dietary acrylamide, Adults, EPIC-Soft, Europe, 24-h dietary recall
Original languageEnglish
Pages (from-to)1369-1380
JournalEuropean Journal of Nutrition
Issue number4
Publication statusPublished - 2013
Publication categoryResearch