Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort

Research output: Contribution to journalArticle


The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates P-heterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.


  • Anne E. Cust
  • Nadia Slimani
  • Rudolf Kaaks
  • Marit van Bakel
  • Carine Biessy
  • Pietro Ferrari
  • Martine Laville
  • Anne Tjonneland
  • Anja Olsen
  • Kim Overvad
  • Martin Lajous
  • Francoise Clavel-Chapelon
  • Marie-Christine Boutron-Ruault
  • Jakob Linseisen
  • Sabine Rohrmann
  • Ute Noethlings
  • Heiner Boeing
  • Domenico Palli
  • Sabina Sieri
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Guri Skeie
  • Dagrun Engeset
  • Inger Torhild Gram
  • J. Ramon Quiros
  • Paula Jakszyn
  • Maria Jose Sanchez
  • Nerea Larranaga
  • Carmen Navarro
  • Eva Ardanaz
  • Göran Berglund
  • Eva Lundin
  • Goeran Hallmans
  • H. Bas Bueno-de-Mesquita
  • Huaidong Du
  • Petra H. M. Peeters
  • Shelia Bingham
  • Kay-Tee Khaw
  • Naomi E. Allen
  • Timothy J. Key
  • Mazda Jenab
  • Elio Riboli
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology


  • insulin, glycemic index, diet, neoplasms, dietary fiber, endometrial, nutrition assessment, dietary carbohydrates, cohort studies
Original languageEnglish
Pages (from-to)912-923
JournalAmerican Journal of Epidemiology
Issue number8
Publication statusPublished - 2007
Publication categoryResearch