Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

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Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort. / Vermeulen, Esther; Zamora-Ros, Raul; Duell, Eric J.; Lujan-Barroso, Leila; Boeing, Heiner; Aleksandrova, Krasimira; Bueno-de-Mesquita, H. Bas; Scalbert, Augustin; Romieu, Isabelle; Fedirko, Veronika; Touillaud, Marina; Fagherazzi, Guy; Perquier, Florence; Molina-Montes, Esther; Chirlaque, Maria-Dolores; Argueelles, Marcial Vicente; Amiano, Pilar; Barricarte, Aurelio; Pala, Valeria; Mattiello, Amalia; Saieva, Calogero; Tumino, Rosario; Ricceri, Fulvio; Trichopoulou, Antonia; Vasilopoulou, Effie; Ziara, Gianna; Crowe, Francesca L.; Khaw, Kay-Thee; Wareham, Nicholas J.; Vasilopoulou, Effie; Ziara, Gianna; Crowe, Francesca L.; Khaw, Kay-Thee; Wareham, Nicholas J.; Lukanova, Annekatrin; Grote, Verena A.; Tjonneland, Anne; Halkjaer, Jytte; Bredsdorff, Lea; Overvad, Kim; Siersema, Peter D.; Peeters, Petra H. M.; May, Anne M.; Weiderpass, Elisabete; Skeie, Guri; Hjartaker, Anette; Landberg, Rikard; Johansson, Ingegerd; Sonestedt, Emily; Ericson, Ulrika; Riboli, Elio; Gonzalez, Carlos A.

In: American Journal of Epidemiology, Vol. 178, No. 4, 2013, p. 570-581.

Research output: Contribution to journalArticle

Harvard

Vermeulen, E, Zamora-Ros, R, Duell, EJ, Lujan-Barroso, L, Boeing, H, Aleksandrova, K, Bueno-de-Mesquita, HB, Scalbert, A, Romieu, I, Fedirko, V, Touillaud, M, Fagherazzi, G, Perquier, F, Molina-Montes, E, Chirlaque, M-D, Argueelles, MV, Amiano, P, Barricarte, A, Pala, V, Mattiello, A, Saieva, C, Tumino, R, Ricceri, F, Trichopoulou, A, Vasilopoulou, E, Ziara, G, Crowe, FL, Khaw, K-T, Wareham, NJ, Vasilopoulou, E, Ziara, G, Crowe, FL, Khaw, K-T, Wareham, NJ, Lukanova, A, Grote, VA, Tjonneland, A, Halkjaer, J, Bredsdorff, L, Overvad, K, Siersema, PD, Peeters, PHM, May, AM, Weiderpass, E, Skeie, G, Hjartaker, A, Landberg, R, Johansson, I, Sonestedt, E, Ericson, U, Riboli, E & Gonzalez, CA 2013, 'Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort', American Journal of Epidemiology, vol. 178, no. 4, pp. 570-581. https://doi.org/10.1093/aje/kwt026

APA

Vermeulen, E., Zamora-Ros, R., Duell, E. J., Lujan-Barroso, L., Boeing, H., Aleksandrova, K., ... Gonzalez, C. A. (2013). Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort. American Journal of Epidemiology, 178(4), 570-581. https://doi.org/10.1093/aje/kwt026

CBE

Vermeulen E, Zamora-Ros R, Duell EJ, Lujan-Barroso L, Boeing H, Aleksandrova K, Bueno-de-Mesquita HB, Scalbert A, Romieu I, Fedirko V, Touillaud M, Fagherazzi G, Perquier F, Molina-Montes E, Chirlaque M-D, Argueelles MV, Amiano P, Barricarte A, Pala V, Mattiello A, Saieva C, Tumino R, Ricceri F, Trichopoulou A, Vasilopoulou E, Ziara G, Crowe FL, Khaw K-T, Wareham NJ, Vasilopoulou E, Ziara G, Crowe FL, Khaw K-T, Wareham NJ, Lukanova A, Grote VA, Tjonneland A, Halkjaer J, Bredsdorff L, Overvad K, Siersema PD, Peeters PHM, May AM, Weiderpass E, Skeie G, Hjartaker A, Landberg R, Johansson I, Sonestedt E, Ericson U, Riboli E, Gonzalez CA. 2013. Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort. American Journal of Epidemiology. 178(4):570-581. https://doi.org/10.1093/aje/kwt026

MLA

Vancouver

Author

Vermeulen, Esther ; Zamora-Ros, Raul ; Duell, Eric J. ; Lujan-Barroso, Leila ; Boeing, Heiner ; Aleksandrova, Krasimira ; Bueno-de-Mesquita, H. Bas ; Scalbert, Augustin ; Romieu, Isabelle ; Fedirko, Veronika ; Touillaud, Marina ; Fagherazzi, Guy ; Perquier, Florence ; Molina-Montes, Esther ; Chirlaque, Maria-Dolores ; Argueelles, Marcial Vicente ; Amiano, Pilar ; Barricarte, Aurelio ; Pala, Valeria ; Mattiello, Amalia ; Saieva, Calogero ; Tumino, Rosario ; Ricceri, Fulvio ; Trichopoulou, Antonia ; Vasilopoulou, Effie ; Ziara, Gianna ; Crowe, Francesca L. ; Khaw, Kay-Thee ; Wareham, Nicholas J. ; Vasilopoulou, Effie ; Ziara, Gianna ; Crowe, Francesca L. ; Khaw, Kay-Thee ; Wareham, Nicholas J. ; Lukanova, Annekatrin ; Grote, Verena A. ; Tjonneland, Anne ; Halkjaer, Jytte ; Bredsdorff, Lea ; Overvad, Kim ; Siersema, Peter D. ; Peeters, Petra H. M. ; May, Anne M. ; Weiderpass, Elisabete ; Skeie, Guri ; Hjartaker, Anette ; Landberg, Rikard ; Johansson, Ingegerd ; Sonestedt, Emily ; Ericson, Ulrika ; Riboli, Elio ; Gonzalez, Carlos A. / Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort. In: American Journal of Epidemiology. 2013 ; Vol. 178, No. 4. pp. 570-581.

RIS

TY - JOUR

T1 - Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

AU - Vermeulen, Esther

AU - Zamora-Ros, Raul

AU - Duell, Eric J.

AU - Lujan-Barroso, Leila

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Bueno-de-Mesquita, H. Bas

AU - Scalbert, Augustin

AU - Romieu, Isabelle

AU - Fedirko, Veronika

AU - Touillaud, Marina

AU - Fagherazzi, Guy

AU - Perquier, Florence

AU - Molina-Montes, Esther

AU - Chirlaque, Maria-Dolores

AU - Argueelles, Marcial Vicente

AU - Amiano, Pilar

AU - Barricarte, Aurelio

AU - Pala, Valeria

AU - Mattiello, Amalia

AU - Saieva, Calogero

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Trichopoulou, Antonia

AU - Vasilopoulou, Effie

AU - Ziara, Gianna

AU - Crowe, Francesca L.

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J.

AU - Vasilopoulou, Effie

AU - Ziara, Gianna

AU - Crowe, Francesca L.

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J.

AU - Lukanova, Annekatrin

AU - Grote, Verena A.

AU - Tjonneland, Anne

AU - Halkjaer, Jytte

AU - Bredsdorff, Lea

AU - Overvad, Kim

AU - Siersema, Peter D.

AU - Peeters, Petra H. M.

AU - May, Anne M.

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Hjartaker, Anette

AU - Landberg, Rikard

AU - Johansson, Ingegerd

AU - Sonestedt, Emily

AU - Ericson, Ulrika

AU - Riboli, Elio

AU - Gonzalez, Carlos A.

PY - 2013

Y1 - 2013

N2 - We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers.

AB - We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers.

KW - esophageal cancer

KW - European Prospective Investigation into Cancer and

KW - Nutrition

KW - flavonoids

KW - intake

U2 - 10.1093/aje/kwt026

DO - 10.1093/aje/kwt026

M3 - Article

VL - 178

SP - 570

EP - 581

JO - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 4

ER -