Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

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Bibtex

@article{bfceca6f54f0414e97c3f24e7a997084,
title = "Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.",
abstract = "Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.",
author = "Lambertsen, {Kate L} and Tomas Deierborg and Rikke Gregersen and Clausen, {Bettina H} and Martin Wirenfeldt and Nielsen, {Helle H} and Ishar Dalmau and Diemer, {Nils H} and Frederik Dagnaes-Hansen and Johansen, {Flemming F} and Armand Keating and Bente Finsen",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)",
year = "2011",
doi = "10.1097/NEN.0b013e31821db3aa",
language = "English",
volume = "70",
pages = "481--494",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "American Association of Neuropathologists",
number = "6",

}