Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens

Research output: Contribution to journalArticle

Abstract

Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.

Details

Authors
  • Mats Merup
  • Vladimir Lazarevic
  • Hareth Nahi
  • Bjorn Andreasson
  • Claes Malm
  • Lars Nilsson
  • Mats Brune
  • Katarina LeBlanc
  • Jack Kutti
  • Gunnar Birgegard
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • conditioning, reduced intensity, myelofibrosis, allogeneic transplantation, Cervantes score
Original languageEnglish
Pages (from-to)367-373
JournalBritish Journal of Haematology
Volume135
Issue number3
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes