Differential molecular and behavioural response to L-DOPA in mice injected with 6-hydroxydopamine in the striatum or in the medial forebrain bundle

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Abstract

Unilateral lesions of nigrostriatal dopamine ( DA) pathways with 6-hydroxydopamine (6-OHDA) can be used to obtain a model of Parkinson's disease in the mouse. In the present study we examine two types of unilateral 6-OHDA lesions in the mouse for their ability to induce stable motor deficits and supersensitive molecular and behavioural response to L-DOPA.

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Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • L-DOPA, 6-OHDA, mice
Original languageEnglish
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedNo

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