Differentiation of diabetes by pathophysiology, natural history, and prognosis

Research output: Contribution to journalReview article


The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.


  • Jay S Skyler
  • George L. Bakris
  • Ezio Bonifacio
  • Tamara Darsow
  • Robert H. Eckel
  • Leif Groop
  • Per-Henrik Groop
  • Yehuda Handelsman
  • Richard A Insel
  • Chantal Mathieu
  • Allison T. McElvaine
  • Jerry P. Palmer
  • Alberto Pugliese
  • Desmond A Schatz
  • Jay M Sosenko
  • John P H Wilding
  • Robert E Ratner
External organisations
  • University of Miami
  • University of Chicago
  • Dresden University of Technology
  • University of Helsinki
  • Baker IDI Heart and Diabetes Institute
  • Folkhälsan Research Center
  • Juvenile Diabetes Research Foundation
  • Catholic University of Leuven
  • University of Washington
  • University of Florida
  • Aintree University Hospital
  • American Diabetes Association
  • University of Colorado
  • Metabolic Institute of America
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)241-255
Number of pages15
Issue number2
Publication statusPublished - 2017 Feb 1
Publication categoryResearch