Diffuse reflectance spectroscopy of liver tissue

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).
The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Applied Mechanics
  • Atom and Molecular Physics and Optics

Keywords

  • Diffuse reflectance spectroscopy, liver tissue, optical properties.
Original languageEnglish
Title of host publication[Host publication title missing]
PublisherSPIE
Pages95314E
Number of pages10
Volume9531
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes
EventSPIE Biophotonics South America 2015 - Rio de Janeiro, Brazil
Duration: 2015 May 232015 May 25

Publication series

Name
Volume9531
ISSN (Print)1996-756X
ISSN (Electronic)0277-786X

Conference

ConferenceSPIE Biophotonics South America 2015
CountryBrazil
CityRio de Janeiro
Period2015/05/232015/05/25