Diffusion tensor imaging and tractography of the white matter in normal aging: The rate-of-change differs between segments within tracts

Research output: Contribution to journalArticle

Abstract

Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.

Details

Authors
Organisations
External organisations
  • Uppsala University
  • Karolinska Institutet
  • University of Groningen
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Journal Article
Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalMagnetic Resonance Imaging
Volume45
Publication statusPublished - 2018 Jan
Publication categoryResearch
Peer-reviewedYes