Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes

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T1 - Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes

AU - Geborek, Pierre

AU - Forslind, K

AU - Wollheim, Frank

PY - 1989

Y1 - 1989

N2 - A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.

AB - A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.

KW - laser Doppler technique

KW - rheumatoid arthritis

U2 - 10.1136/ard.48.4.281

DO - 10.1136/ard.48.4.281

M3 - Article

VL - 48

SP - 281

EP - 286

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 1468-2060

IS - 4

ER -