Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

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Abstract

A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.

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  • Biochemistry and Molecular Biology
Original languageEnglish
Pages (from-to)276-279
JournalJournal of Chromatography A
Volume664
Issue number2
Publication statusPublished - 1994
Publication categoryResearch
Peer-reviewedYes