Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma

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Bibtex

@article{857cc6be827f4c1286d0bfdfcc4d9bdc,
title = "Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma",
abstract = "Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.",
keywords = "Apoptosis, Chemoresistance, Epi-enprioline, Neuroblastoma, Vincristine",
author = "Wondossen Sime and Mohamed Jema{\`a} and Yasmin Abassi and Lasorsa, {Vito Alessandro} and K{\o}hler, {Julie Bonne} and Karin Hansson and Daniel Bexell and Martin Michaelis and Jindrich Cinatl and Daniel Strand and Mario Capasso and Ramin Massoumi",
year = "2020",
doi = "10.3390/ijms21186577",
language = "English",
volume = "21",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI AG",
number = "18",

}